Anastrozole (Arimidex)

Common brand name: Arimidex

Why is this drug prescribed?
Anastrozole is a hormonal treatment used to treat breast cancer. Anastrozole lowers serum estrogen levels and is commonly used in postmenopausal women

How and when should Anastrozole be used?
The daily dose of anastrozole is a 1-mg tablet. Take anastrozole once a day, at the same time each day. The tablet should be swallowed whole. Do not crush or break up the tablet before taking it. Anastrozole may be taken with or without food. Take with food if it causes an upset stomach.

The length of time you are prescribed anastrozole might vary, depending on your doctor’s recommendation. Take this medication exactly as prescribed. Do not increase your dose or take anastrozole more often than directed, as there will be no additional benefit and the risk of side effects may increase.

NEVER stop taking anastrozole without consulting your doctor. Ask your doctor or pharmacist about refilling your prescription, and to explain any part of the directions for taking this medication that you do not understand.

• Tell your doctor if you are allergic to anastrozole or any other drug. Tell your doctor if you have stomach problems or liver disease. Tell your doctor of any other prescription, over-the-counter, herbal, or vitamin products that you are taking.
• Although anastrozole is usually used in post-menopausal women, if there is any chance that you might become pregnant, it is important to use a barrier method of birth control (such as condoms or a diaphragm) while taking Anastrozole. Oral contraceptives (the "pill") are not recommended, since they might change the effects of Anastrozole. The IUD (intrauterine device) also is not recommended while taking Anastrozole. Ask your health care provider about the birth control method that is right for you.
• Tell your health care provider right away if you are planning to become pregnant, become pregnant, or are planning to breastfeed.
• Continue using a barrier birth control method for about 2 months after you have stopped taking Anastrozole.

• Nausea — This generally decreases over time. If needed, anti-nausea medications can be prescribed or over-the-counter brands can be recommended.
• Weakness or fatigue
• Changes in bowel movements — You might experience constipation or diarrhea; consult your health care provider.
• Hot flashes — These will decrease in frequency and intensity over time. Consult your physician if hot flashes and/or night sweats become bothersome.
• Headaches — You may try Tylenol (acetaminophen) or ibuprofen to relieve any headache that occurs. Report any headaches or other discomforts to your physician.
• Cough — Over-the-counter cough suppressants can be recommended.
• Bone pain — May lessen with continued use. Talk with your doctor about use of an analgesic.

Please note: The side effects listed are the most common. All possible side effects are not included. Always contact your doctor if you have questions about your personal situation.

When should I call my doctor?
Call your doctor if you:

• Have uncontrolled vomiting
• Develop any abnormal vaginal bleeding
• Increased swelling in any of the extremities
• Develop a rash
• Have difficult breathing
• Have severe mood swings/confusion/anxiety
• Have pain or burning during urination
• Develop flu-like symptoms
• Have palpitations
• Have any other unusual symptoms
• Have any questions or concerns

What should I do if I forget a dose?
If a dose is missed, simply take it as soon as possible. However, if it is close to when you are scheduled to take your next dose, simply skip the missed dose and proceed with your regular schedule. Do not take a double dose.

• Anastrozole should be kept in its original container, tightly sealed and away from children.
• Keep it out of the reach of children.
• Never share your medication with anyone.
• Store this drug at room temperature and away from sunlight, heat, and moisture. (Do not store it in the bathroom or near the kitchen sink).
• Never take outdated medications. Some medication prescription labels list an expiration date. If such a date is not on your medication label or if you are unsure how old a medication is, call your pharmacy.

This information is not intended to replace the medical advice of your doctor or health care provider. Please consult your health care provider for advice about a specific medical condition.

This handout summarizes information to help you understand and safely take your medication. Other information--not included in this handout--may be important for you to know because of your unique health status. Ask your doctor and/or pharmacist for more information on the medications prescribed for you and your unique health care needs.