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  Health Information Center  :  B  :  Breast Cancer

 Determining Your Breast Cancer Risk

 


What is breast cancer?
In breast cancer, a cell can divide (reproduce without control), forming a malignant tumor. This most commonly occurs in the milk duct, but can also occur in the lobule.

Breast cancer facts

  • Lifetime risk for U.S. women is 1 in 8.
  • The majority of women who develop breast cancer are over 50.
  • Breast cancer is the second leading cause of cancer deaths in women (second only to lung cancer).

What are the risk factors for breast cancer?

  • Increasing age.
  • Having cancer in one breast (may develop in the other breast).
  • Late menopause (after age 50).
  • Getting your period early in life (before age 12).
  • Having your first child after age 30.
  • Never having children.
  • Family history for breast cancer in an immediate family member (mother, sister or daughter).
  • Taking long-term estrogen replacement therapy.
  • Having a breast biopsy show
    -atypical ductal hyperplasia or
    -lobular carcinoma in situ

How can I protect myself from breast cancer?

  • Examine your breasts each month.
  • Have a breast exam performed by a healthcare provider at least once a year.
  • Get a mammogram (first mammogram by age 40).
  • Know your family history. Consider genetic testing if your history includes:
    -Breast cancer in two or more close relatives (such as a mother and sister).
    -Early onset of breast cancer in family members (before age 45).
    -History of breast cancer in more than one generation.
    -Cancer in both breasts that occurs in one or more family members.
    -Frequent occurrences of ovarian cancer.
  • Know your Gail score (breast cancer risk number)
  • Consider ductal lavage
    -if your Gail score is >1.7%
    -if you have a history of atypical cells (from a breast biopsy)
    -if you have a history of breast cancer
    -if you carry the breast cancer gene
    -if you have taken hormone replacement therapy for more than 10 years

What is my Gail score?
The Gail score is a number that estimates your 5-year and lifetime risk of developing breast cancer. This number is calculated using a scientifically validated method called the Gail model.

The Gail model risk factor number, i.e., the Gail score, is calculated based on the following risk factors:

Age ________
Race ________
Age at first menses ________
Age at first full-term pregnancy ________
Number of mother, sisters or daughters with breast cancer ________
Number of breast biopsies ________
History of atypical hyperplasia on biopsy ________
Your Gail score is:_________
The 5 year risk number ________
The lifetime risk number ________

Remember, even if you have a low or normal Gail score, always continue monthly self breast exams, regular mammograms and ongoing breast cancer risk assessments.

What is ductal lavage?

  • 95% of breast cancers develop in the lining of the milk duct system.
  • Ductal lavage is a minimally invasive procedure used to wash cells from the milk ducts. These cells are examined for any changes, i.e., pre-cancerous changes.

Why is ductal lavage important?

  • Ductal lavage can detect atypical, pre-cancerous and cancerous conditions in the breast.
  • Ductal lavage can sometimes detect these conditions even before they can be seen on a mammogram or ultrasound.
  • Most breast cancers develop over a period of 8-10 years before detection by standard methods.
  • Treatment decisions can be made based on the individual patient's risk assessment which includes;
    1. The Gail score
    2. Genetic testing
    3. Ductal lavage results

1.  Normal ducts
2.  Intraductal Hyperplasia
3.  Atypical Ductal Hyperplasia
4.  Ductal Carcinoma In Situ
5.  Invasive Ductal Cancer








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